Cancer cell migration and invasion

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Cancer cell migration and invasion

Postby wolfhnd on May 23rd, 2009, 6:55 pm 

Regulation of the actin cytoskeleton in cancer cell migration and invasion

Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and the vasculature, and ultimately to metastasize. Cell
migration is the sum of multi-step processes initiated by the formation of membrane protrusions in response to migratory and chemotactic stimuli.
The driving force for membrane protrusion is localized polymerization of submembrane actin filaments. Recently, several studies revealed that
molecules that link migratory signals to the actin cytoskeleton are upregulated in invasive and metastatic cancer cells. In this review, we
summarize recent progress on molecular mechanisms of formation of invasive protrusions used by tumor cells, such as lamellipodia and
invadopodia, with regard to the functions of key regulatory proteins of the actin cytoskeleton; WASP family proteins, Arp2/3 complex, LIMkinase,
cofilin, and cortactin.

http://www.sh.lsuhsc.edu/IntraGrad/slid ... REVIEW.pdf
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