Disordered' amino acids provide wiggle room

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Disordered' amino acids provide wiggle room

Postby wolfhnd on June 11th, 2009, 8:48 pm 

'Disordered' amino acids may really be there to provide wiggle room for signaling protein

– Sections of proteins previously thought to be disordered may in fact have an unexpected biological role – providing certain proteins room to move -- according to a study published by researchers at Fox Chase Cancer Center in this month's issue of the journal Structure (Cell Press).

http://www.eurekalert.org/pub_releases/ ... 052609.php

Re: Disordered' amino acids provide wiggle room

Postby BioWizard on June 13th, 2009, 11:29 am 

Instrinsic disorder within protein segments or whole proteins is more prominent in eukaryotes than prokaryotes, and it's a hallmark of proteins that interaction with several partners (promiscuous proteins). The intrinsic disorder is the result of having a "shallow" energy folding landscape, which allows the protein to assume one of several conformations, each of which allows it to serve as an interacting partner for one or more of several interacting proteins. This is believed to enormously increase the complexity of protein-protein interactions in higher-order organisms.
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