LH inhibitor: Could it work?

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LH inhibitor: Could it work?

Postby caters on September 13th, 2017, 12:10 pm 

I was thinking about how the aliens in my generation ship story sterilize people that have a genetic disease but don't sterilize carriers. The complete spermicide for males makes perfect sense. But with females, it is more complicated. What complicates things with females? The menstrual cycle of course. What I am aiming for is a way to inhibit ovulation without also inhibiting menstruation. So I looked at graphs of the menstrual cycle and the hormones and thought that since LH is the 1 hormone that triggers ovulation in the first place, an LH inhibitor would stop ovulation from happening at LH levels that would normally trigger ovulation. And because it is not estrogen or progesterone(both of which stop periods and estrogen, if taken at the right time can actually act as a natural fertility drug, raising the chances of having twins and higher order multiples), those 2 hormones should still cycle as normal with dips corresponding to menstruation. So basically, ovulation has stopped but there is still a menstrual cycle.

But could a direct inhibitor of LH stop ovulation without stopping periods? Or would it have the same amenorrhea effects as estrogen and progesterone do along with the direct effect of anovulation?
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Re: LH inhibitor: Could it work?

Postby BioWizard on September 13th, 2017, 4:39 pm 

Isn't the process of ovulation itself involved in orchestrating the menstual cycle?
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Re: LH inhibitor: Could it work?

Postby caters on September 13th, 2017, 10:10 pm 

BioWizard » September 13th, 2017, 4:39 pm wrote:Isn't the process of ovulation itself involved in orchestrating the menstual cycle?


I am not so sure on that because there are cases where a woman ovulates without a period(like the first ovulation after pregnancy) and there are cases where a woman has a period but doesn't ovulate(Menarche being 1 of those cases). So surely, if I want to inhibit ovulation in women with genetic disease, there should be some way to do that without causing amenorrhea.
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Re: LH inhibitor: Could it work?

Postby BioWizard on October 18th, 2017, 4:47 pm 

caters » 13 Sep 2017 09:10 pm wrote:
BioWizard » September 13th, 2017, 4:39 pm wrote:Isn't the process of ovulation itself involved in orchestrating the menstual cycle?


I am not so sure on that because there are cases where a woman ovulates without a period(like the first ovulation after pregnancy) and there are cases where a woman has a period but doesn't ovulate(Menarche being 1 of those cases). So surely, if I want to inhibit ovulation in women with genetic disease, there should be some way to do that without causing amenorrhea.


That just means that the "orchestration" between the two events is screwed up in those instances. It doesn't mean that they are independent in normal women.
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