Peripheral proteins

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Peripheral proteins

Postby Hendrick Laursen on June 14th, 2015, 4:19 pm 

Hi,

I had a quarrel with my biochemistry professor today.
He tends to believe element of cytoskeleton (such as actin) are peripheral membranous protiens,
And me judging they're not.

What's your stand?
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Re: Peripheral proteins

Postby BioWizard on June 14th, 2015, 6:43 pm 

I'm inclined to side with you.
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Re: Peripheral proteins

Postby Watson on June 14th, 2015, 9:28 pm 

I had thought the good money would be on the professor, over the student. Why is it not necessarily true in this case?

Although, I did have a university arts professor that I was warned against, and as it turned out was not very knowledgeable on the subject at hand, and was to busy installing works in a restaurant to show up at class.

Just wondering why this is the case in your case.
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Re: Peripheral proteins

Postby BioWizard on June 14th, 2015, 9:44 pm 

Professors can't be right all the time. Nobody can. (the lazy answer)
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Re: Peripheral proteins

Postby Hendrick Laursen on June 15th, 2015, 5:16 am 

Well,
The matter costed me a couple negative mark, challenging the professor in front of 200 students.
Never mind. Thanks for your response.
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Re: Peripheral proteins

Postby neuro on June 15th, 2015, 8:47 am 

Hendrick, before challenging him again, please look at the definition of "peripheral membrane protein".
According to most, "peripheral membrane proteins" are not membrane proteins. They are soluble proteins that transiently interact with a membrane. In particular, they interact not with the membrane itself (lipidic matrix) but with integral membrane proteins.

Since many cytoskeletal proteins (and actin in particular) reversibly interact with a number of membrane-associated proteins to perform their mechanical roles (think of adhesion sites and cell motility), I believe they can be correctly referred to as "peripheral" membrane proteins.
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Re: Peripheral proteins

Postby BioWizard on June 15th, 2015, 8:59 am 

I'm glad you raised that point neuro, because it did occur to me, but then I remembered that in most scenarios the cytoskeletal protein would be interacting with an adapter protein that would be recruited by the integral proteins. In other words, the cytoskeletal proteins are associating with peripheral proteins, rather than themselves being peripheral proteins. So my suspicion was that the professor was extending the definition.
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Re: Peripheral proteins

Postby neuro on June 15th, 2015, 9:22 am 

You're right, Bio.
It generally does not interact with INTEGRAL membrane proteins.
My mistake.
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Re: Peripheral proteins

Postby BioWizard on June 15th, 2015, 9:37 am 

neuro » 15 Jun 2015 08:22 am wrote:You're right, Bio.
It generally does not interact with INTEGRAL membrane proteins.
My mistake.


I wouldn't call it a mistake neuro, just an alternate interpretation of the definition. Which is what I suspect caused the clash between Hendrick and his prof. I was happy that you brought it up so that Watson may have a more specific answer to his question (since I was too lazy/groggy earlier to bring all of this up on my own).

That's also why I told Hendrick "I'm inclined to side with you" and not "you are correct and your prof is wrong".
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