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Chelated mineral absorption and metabolism

PostPosted: August 26th, 2015, 4:37 am
by Palladium106
Some mineral supplements include their minerals in organic, chelated form. For example magnesium aspartate or iron bis glycinate. Some claim that they have a higher bioavailability than inorganic forms (eg. MgCl2 or Fe(CO)5). Some claim that some chelates are preferentially directed to some organs.

The theory is that amino acid chelates are taken up by peptide transporters in the small intestine. Thus avoiding mineral competition or channel saturation. Some say that specific amino acids are more likely to be taken up by some tissues, and that this correlation can be used to direct minerals by intelligently selecting a chelating partner.

Can anyone comment or give me a pointer in the right direction? Most claims I think are dubious, but then there are studies like one showing that an Mg chelate outperformed inorganic Mg and even another chelate with equivalent apparent bioavailability for nootropic effects.

Re: Chelated mineral absorption and metabolism

PostPosted: August 26th, 2015, 7:57 pm
by BioWizard
It's not possible to make a blanket statement about this. It all depends on the relative affinity of the metal to the chelating agent vs its affinity to other agents in the gut that may impair absorption vs affinity to the transporter. Chelating agents that can prevent binding of the mineral to other agents that deter absorption will improve bioavailability (assuming the chelating agent itself doesn't interfer with absorption), and vice versa.