New treatment for pancreatic cancer using Nanoparticle

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New treatment for pancreatic cancer using Nanoparticle

Postby RamyaS on March 24th, 2015, 6:46 am 

UCLA researchers create new method that targets tumors with the same effectiveness but a significant reduction in both side effects and cost.
Pancreatic cancer:
Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass. These cancer cells have the ability to invade other parts of the body.[1] There are a number of types of pancreatic cancer. The most common, pancreatic adenocarcinoma, accounts for about 85% of cases, and the term "pancreatic cancer" is sometimes used to refer only to that type. These adenocarcinomas start within the part of the pancreas which make digestive enzymes. Several other types of cancer, which collectively represent the majority of the non-adenocarcinomas, can also arise from these cells.
New research:
Recent research has found that combining gemcitabine with another drug called paclitaxel can improve the overall treatment effect. In the current method, Abraxane — a nano complex containing paclitaxel — and gemcitabine are given separately, which works to a degree, but because the drugs may stay in the body for different lengths of time, the combined beneficial effect is not fully synchronized.Initially the treatment tested in mice.In the mice that received the drugs inside the nanoparticle, pancreas tumors shrank dramatically.And also tumor spread, to nearby organs was eradicated in these mice.
Source:UCLA
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Re: New treatment for pancreatic cancer using Nanoparticle

Postby Braininvat on March 24th, 2015, 11:45 am 

Thanks, Ram! Can you explain for us how the nanocomplex works better in targeting the tumor, and how it releases the paclitaxel?
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Re: New treatment for pancreatic cancer using Nanoparticle

Postby RamyaS on March 25th, 2015, 12:02 am 

I am not study nanotechnology.I have interested in it.My answer is Cancer is caused by an accumulation of genetic mutations.These mutations cause changes in the expression of proteins that the altered genes produce.Small interfering RNAs are able to prevent the production of proteins in the first place by specifically intercepting and destroying messenger RNA, which represents an intermediate step between genes and proteins. The use of siRNA helps to explain aspects of basic cell biology by specifically reducing the production of proteins of interest and promises to improve treatment of undruggable targets.The nanocomplex features a tumor penetrating domain that binds to receptors that are over-expressed on the surface of certain cancer cells.Upon binding, a mechanism is activated that drives the nanocomplex deep into tumor tissue and allows it to internalize in cells.When the nanocomplex enters a cell, it is encapsulated in a membrane known as the endosome. A cell penetrating domain on the nanocomplex helps it cross the endosomal membrane, allowing the siRNA to reach the cell’s main compartment where it can start interfering with protein production.For each nanocomplex, we measured its ability to bind to receptors on cancer cells,to internalize in the cells, to escape from the endosome, and ultimately, to deliver the siRNA.
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Re: New treatment for pancreatic cancer using Nanoparticle

Postby NittanyJ on December 14th, 2015, 7:08 am 

Thanks for sharing. Also pancreatic cancer can be treated with special nanodevices which are made to deliver drug to the targeted area.
Also, scientists are developing a sensor which can help detect cancer marks in blood samples.
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