Proteins may have kick started life

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Proteins may have kick started life

Postby BioWizard on March 4th, 2018, 5:56 pm 

Interesting paper in Nature Communications

https://www.nature.com/articles/s41467-017-02742-3

The prebiotic replication of information-coding molecules is a central problem concerning life’s origins. Here, we report that amyloids composed of short peptides can direct the sequence-selective, regioselective and stereoselective condensation of amino acids. The addition of activated DL-arginine and DL-phenylalanine to the peptide RFRFR-NH2 in the presence of the complementary template peptide Ac-FEFEFEFE-NH2 yields the isotactic product FRFRFRFR-NH2, 1 of 64 possible triple addition products, under conditions in which the absence of template yields only single and double additions of mixed stereochemistry. The templating mechanism appears to be general in that a different amyloid formed by (Orn)V(Orn)V(Orn)V(Orn)V-NH2 and Ac-VDVDVDVDV-NH2 is regioselective and stereoselective for N-terminal, L-amino-acid addition while the ornithine-valine peptide alone yields predominantly sidechain condensation products with little stereoselectivity. Furthermore, the templating reaction is stable over a wide range of pH (5.6–8.6), salt concentration (0–4 M NaCl), and temperature (25–90 °C), making the amyloid an attractive model for a prebiotic peptide replicating system.
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Re: Proteins may have kick started life

Postby mitchellmckain on March 4th, 2018, 6:36 pm 

The term "prebiotic evolution" suggests developments in the direction of "metabolism first" theories of abiogenesis which I have mentioned and advocated elsewhere.

This is where others may want to look for some understanding when all they see in the quote above is word salad. Here is a link which I found.
http://what-when-how.com/molecular-biol ... r-biology/
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Re: Proteins may have kick started life

Postby Katrin on March 26th, 2018, 5:39 pm 

where are the Archaea-and Cyano-bacterias from ?
Where have they been before the big bang ?
Were they frozen in the big global planet before ?
And was there life-exist before ?
Have these bacterias all genes for the whole earth evolution in them.

Who were the creatures who projected this ?
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Re: Proteins may have kick started life

Postby Watson on March 26th, 2018, 5:46 pm 

Well it will be interesting to see if you get a reply from Bio?
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Re: Proteins may have kick started life

Postby Braininvat on March 26th, 2018, 6:43 pm 

He was logged on here at 10:25 am (mountain time zone, so 12:25 pm EDT), about ten minutes after the bombshell thread was started. Did not post. I find that a bit puzzling.
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Re: Proteins may have kick started life

Postby Watson on March 26th, 2018, 6:51 pm 

Yes I noticed that.
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Re: Proteins may have kick started life

Postby Braininvat on March 26th, 2018, 7:24 pm 

Might be busy these days. Look forward to more on prebiotic peptide replication and the amyloid model. If it holds up well in early earth conditions of swinging pH and salinity and temp then it would sure be a strong model. Maybe this could go with that abiogenesis thread we had last year....
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Re: Proteins may have kick started life

Postby BioWizard on March 28th, 2018, 4:43 pm 

Braininvat » 26 Mar 2018 05:43 pm wrote:He was logged on here at 10:25 am (mountain time zone, so 12:25 pm EDT), about ten minutes after the bombshell thread was started. Did not post. I find that a bit puzzling.


Braininvat » 26 Mar 2018 06:24 pm wrote:Might be busy these days.


LOL yep, sorry about that.

Also, I didn't see the thread right away. Sometimes I open the browser on my phone and it will go to this site and show me as logged in. Doesn't necessarily mean I'm reading.
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Re: Proteins may have kick started life

Postby BioWizard on March 28th, 2018, 4:44 pm 

Katrin » 26 Mar 2018 04:39 pm wrote:where are the Archaea-and Cyano-bacterias from ?
Where have they been before the big bang ?
Were they frozen in the big global planet before ?
And was there life-exist before ?
Have these bacterias all genes for the whole earth evolution in them.

Who were the creatures who projected this ?


Why do you think anything needs to have existed before the big bang, for it to have existed after it?
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Re: Proteins may have kick started life

Postby Event Horizon on March 28th, 2018, 8:02 pm 

I would love to know how and when the proteins were contained in a lipid Cell. How it happened, and what happened next would be a very interesting story I think.
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