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SciameriKen » May 8th, 2017, 10:03 am wrote:When I get some more time I'll look into this a bit more - for now though - what kind of exercise are you doing these days?
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SciameriKen » February 16th, 2016, 10:52 pm wrote:Greetings all -
I created a new petition at whitehouse.gov
https://petitions.whitehouse.gov//petit ... ule-i-drug
Essentially the goal is to reduce the status of marijuana as a schedule I drug. This classification simply does not make sense, but still the implications are huge as the scientific community has great difficulty in studying the impacts of this drug on what is estimated to be roughly 2.5 million regular users, and countless casual users.
Thank you for your support!
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https://www.sciencedaily.com/releases/20...112400.htm
RELEASE: Memory performance decreases with increasing age. Cannabis can reverse these ageing processes in the brain. This was shown in mice by scientists at the University of Bonn with their colleagues at The Hebrew University of Jerusalem (Israel). Old animals were able to regress to the state of two-month-old mice with a prolonged low-dose treatment with a cannabis active ingredient. This opens up new options, for instance, when it comes to treating dementia. The results are now presented in the journal Nature Medicine.
Like any other organ, our brain ages. As a result, cognitive ability also decreases with increasing age. This can be noticed, for instance, in that it becomes more difficult to learn new things or devote attention to several things at the same time. This process is normal, but can also promote dementia. Researchers have long been looking for ways to slow down or even reverse this process.
Scientists at the University of Bonn and The Hebrew University of Jerusalem (Israel) have now achieved this in mice. These animals have a relatively short life expectancy in nature and display pronounced cognitive deficits even at twelve months of age. The researchers administered a small quantity of THC, the active ingredient in the hemp plant (cannabis), to mice aged two, twelve and 18 months over a period of four weeks.
Afterwards, they tested learning capacity and memory performance in the animals -- including, for instance, orientation skills and the recognition of other mice. Mice who were only given a placebo displayed natural age-dependent learning and memory losses. In contrast, the cognitive functions of the animals treated with cannabis were just as good as the two-month-old control animals. "The treatment completely reversed the loss of performance in the old animals," reported Prof. Andreas Zimmer from the Institute of Molecular Psychiatry at the University of Bonn and member of the Cluster of Excellence ImmunoSensation.
Years of meticulous research
This treatment success is the result of years of meticulous research. First of all, the scientists discovered that the brain ages much faster when mice do not possess any functional receptors for THC. These cannabinoid 1 (CB1) receptors are proteins to which the substances dock and thus trigger a signal chain. CB1 is also the reason for the intoxicating effect of THC in cannabis products, such as hashish or marihuana, which accumulate at the receptor. THC imitates the effect of cannabinoids produced naturally in the body, which fulfil important functions in the brain. "With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces," says Prof. Zimmer. "When the activity of the cannabinoid system declines, we find rapid ageing in the brain."
To discover precisely what effect the THC treatment has in old mice, the researchers examined the brain tissue and gene activity of the treated mice. The findings were surprising: the molecular signature no longer corresponded to that of old animals, but was instead very similar to that of young animals. The number of links between the nerve cells in the brain also increased again, which is an important prerequisite for learning ability. "It looked as though the THC treatment turned back the molecular clock," says Zimmer.
Next step: clinical trial on humans
A low dose of the administered THC was chosen so that there was no intoxicating effect in the mice. Cannabis products are already permitted as medications, for instance as pain relief. As a next step, the researchers want to conduct a clinical trial to investigate whether THC also reverses ageing processes in the brain in humans and can increase cognitive ability.
The North Rhine-Westphalia science minister Svenja Schulze appeared thrilled by the study: "The promotion of knowledge-led research is indispensable, as it is the breeding ground for all matters relating to application. Although there is a long path from mice to humans, I feel extremely positive about the prospect that THC could be used to treat dementia, for instance."
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Heavy_Water » May 8th, 2017, 11:59 am wrote:
You'll not get my signature, good sir. As I am of the opinion that this country needs less access to any mind-altering substance. As cannabis sativa most certainly is. This includes alcohol.
No prude, I. In fact I used to imbibe in drink and recreational drugs in prodigious quantities in my younger years. I no longer do, save an occasional glass of wine--or two--with dinner with my wife a couple times a week. Now working in the Health Care Industry, I have seen firsthand the mind-numbing amount of destruction that drug and alcohol abuse have caused.
Riddle me this, Batman.......you are about to undergo surgery. You're on the bed, and the anasthesia is just beginning to put you under. As you drift off, your surgeon walks up to you and smiles and introduce himself, informing you that he'll be doing the honors.
You catch a faint whiff of pot on him.
What does this do to your confidence level? Increase or decrease?
LOL
Hope this helps.
Cheers.
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Heavy_Water » Mon May 08, 2017 5:59 pm wrote:SciameriKen » February 16th, 2016, 10:52 pm wrote:Greetings all -
I created a new petition at whitehouse.gov
https://petitions.whitehouse.gov//petit ... ule-i-drug
Essentially the goal is to reduce the status of marijuana as a schedule I drug. This classification simply does not make sense, but still the implications are huge as the scientific community has great difficulty in studying the impacts of this drug on what is estimated to be roughly 2.5 million regular users, and countless casual users.
Thank you for your support!
You'll not get my signature, good sir. As I am of the opinion that this country needs less access to any mind-altering substance. As cannabis sativa most certainly is. This includes alcohol.
No prude, I. In fact I used to imbibe in drink and recreational drugs in prodigious quantities in my younger years. I no longer do, save an occasional glass of wine--or two--with dinner with my wife a couple times a week. Now working in the Health Care Industry, I have seen firsthand the mind-numbing amount of destruction that drug and alcohol abuse have caused.
Riddle me this, Batman.......you are about to undergo surgery. You're on the bed, and the anasthesia is just beginning to put you under. As you drift off, your surgeon walks up to you and smiles and introduce himself, informing you that he'll be doing the honors.
You catch a faint whiff of pot on him.
What does this do to your confidence level? Increase or decrease?
LOL
Hope this helps.
Cheers.
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Athena » Mon May 08, 2017 5:36 pm wrote:SciameriKen » May 8th, 2017, 10:03 am wrote:When I get some more time I'll look into this a bit more - for now though - what kind of exercise are you doing these days?
Laugh, that is off topic, but hey, this thread has served its purpose and it is time to repurpose it.
I stopped walking when my dog died and focused on swimming until I was reminded in my study of health issues that weight-bearing exercise is needed for healthy bones. Now I am getting serious about weight bearing and resistant exercises. My apartment has exercise equipment in areas I move through most often, so I am tempted to use it when I walk to the toilet or the kitchen. I have determined to do just a few exercises when I pass by and do them often. This way it is not a big decision to set aside the time, and I don't need a lot of energy for a long period of exercise. It is short and easy. If doing the short exercises as I am doing now, becomes more of habit, it will be easier to keep this up when the days are hot.
I have also returned to evening walks, to improve digestion and get the weight bearing exercise.
I could take the bus to the pool and should, but having a car made me lazy, and right not my daughter is using my car until her transmission is fixed. When I get my car back I will go to the pool hopefully 4 times a week.
I am sure the heat of summer will improve my motivation to go swimming. I also heard the gym is less crowded in the summer, and I like that possibility. I like the pool best when I am the only one in it. Two other people aren't bad, but it is a long and narrow pool and swimming laps gets difficult when more than 3 people are using the pool.
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SciameriKen » May 8th, 2017, 8:33 am wrote:So I did a quick look at Pubmed searching between cannibiniods or marijuana and bone or osteoporosis.
At first glance it would appear cannabinoids are important for bone regulation:
https://www.ncbi.nlm.nih.gov/pubmed/20532878
Endocannabinoids play important roles in bone homeostasis
https://www.ncbi.nlm.nih.gov/pubmed/19634029
Synthetic Cannabinoids rescue ovariectomy induced bone loss and cannabinoid drugs may be useful to combat osteoporosis
However, two recent studies raise questions whether marijuana use is the best strategy for bone strength:
https://www.ncbi.nlm.nih.gov/pubmed/28286929
No Association between Cannabinoids (specifically marijuana usage) use and BMD - NHANES Study
https://www.ncbi.nlm.nih.gov/pubmed/27593602
Heavy Cannabis use is associated with low bone mineral Density
I wonder if the latter is due to lower activity (less exercise) because of the heavy cannabis use - and granted these studies do not eliminate the possibility that smoking eliminated the cannabinoids - but I think they provide evidence that occasional or heavy smoking of marijuana does not provide benefits.
Some general things that do however are increasing vitamin D intake (at least 2,000 IU daily), and calcium - and weight bearing exercises are probably most important. Vitamin C is also important - and I am sure Doogles might have something to add about vitamin K2 :D
lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
Bone remodeling - Wikipedia
https://en.wikipedia.org/wiki/Bone_remodeling
Cannabinoid receptors, located throughout the body, are part of the Endocannabinoid system which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory. Cannabinoid receptors are of a class of cell membrane receptors under the G protein-coupled receptor superfamily.
Cannabinoid receptor - Wikipedia
https://en.wikipedia.org/wiki/Cannabinoid_receptor
O-774
From Wikipedia, the free encyclopedia
O-774 is a classical cannabinoid derivative which acts as a potent agonist for the cannabinoid receptors, with a Ki of 0.6 nM at CB1, and very potent cannabinoid effects in animal studies.[1][2]
Chemistry[hide]
Cannabinoid receptors Cannabinoid receptor type 1 Cannabinoid receptor type 2
Cannabinoids
2-AG 2-AGE, Noladin ether AEA CBC CBL CBD CBDV CBG CBN CBV NADA THC THCV Virodhamine Synthetic cannabinoids
AM-2201 CP-55940 Dimethylheptylpyran HU-210 HU-331 JWH-018 JWH-073 JWH-133 Levonantradol SR144528 WIN 55,212-2
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Researchers are finally studying the medicinal effects of marijuana after many years of marijuana advocates begging and pleading for science to investigate what they already knew – that the plant has the power to ease seizures, help people sleep, and much more. But scientists aren’t studying the stuff you can buy on the street or in dispensaries, so can we trust their conclusions?
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Braininvat » February 17th, 2016, 12:37 pm wrote:Hemp milk (tried it) tastes pretty weird, though.
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wolfhnd » Mon Nov 05, 2018 1:22 am wrote:Can someone explain why legal marijuana is twice as expensive as it's illegal counterparts? Getting criminals out of the selling of marijuana is an important reason I support legalization.
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wolfhnd » November 5th, 2018, 7:01 am wrote:I looked at the tax issue it's about 20% through the chain. Even with high taxes If people can build greenhouses and grow organic tomatoes for $5 a pound they can produce marijuana for a lot less than $300 an ounce. I'm thinking of voting against my states proposal in protest because of the regulation burden. I want it as deregulated as tomatoes. Anyone who wants has to be able to produce it to solve the criminality issue.
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Braininvat » Mon Nov 05, 2018 9:54 am wrote:
Have you seen supermarket tomatoes? I think they should be more regulated, like, requiring them to have flavor.
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MarySmith » March 25th, 2019, 7:45 am wrote:You`ve stolen my thoughts. Everything must be studied before the verdict. We know weed is bad because someone smoked it and got high and he didn`t like himself in this condition. Why did he decide to smoke cannabis in the very beginning? why didn`t he try to smoke parsley or foget-me-nots ?
It`s said that the plant produces many things like CBD and THC and others. CBD causes no high ( according to the World Health Organization, is a “safe and well-tolerable substance with no adverse health effects”)
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After Colorado voted to legalize marijuana in 2012, doctors in Denver noticed a surprising trend. Most people who visited the emergency room for cannabis-related complaints had smoked the drug. But those who ingested the drug were more likely to suffer more severe effects, including psychiatric symptoms and heart problems.
Edibles — marijuana-laced products such as brownies, cookies and gummy bears — are being associated with “medical complications that we never knew were associated with marijuana,” says neuroscientist Nora Volkow, director of the National Institute on Drug Abuse at the National Institutes of Health in Bethesda, Md., who was not involved in the study.
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someguy1 » March 25th, 2019, 7:26 pm wrote:MarySmith » March 25th, 2019, 7:45 am wrote:You`ve stolen my thoughts. Everything must be studied before the verdict. We know weed is bad because someone smoked it and got high and he didn`t like himself in this condition. Why did he decide to smoke cannabis in the very beginning? why didn`t he try to smoke parsley or foget-me-nots ?
It`s said that the plant produces many things like CBD and THC and others. CBD causes no high ( according to the World Health Organization, is a “safe and well-tolerable substance with no adverse health effects”)
To me, CBD makes as little sense as decaf coffee. In both cases the users are utterly missing the point.
The current CBD craze I regard as being along the same lines as hula hoops and pet rocks. Just the latest fad.
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TheVat » March 26th, 2019, 7:50 am wrote:CBD is a medicinal oil which appears to have multiple uses treating seizure disorder, inflammatory conditions and arthritis. It is not psychoactive, nor meant to be. It is no more a fad than shifting your fatty acid intake towards omega-3 FA to reduce inflammatory response. (which "fad" has been working for Mediterranean peoples for centuries)
I appreciate it when members research before posting. Especially if they are well outside of their chosen field.
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