Year of the Rat fears over new Corona Virus

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Re: Year of the Rat fears over new Corona Virus

Postby Serpent on April 2nd, 2020, 12:49 pm 

The Vat -- Idle high school kids in good health could be recruited to rescue crops from rotting in the field, if our government is unable to get its act together

What's wrong with that enormous army? But then, they'll be fighting the floods, hurricanes and wildfires, which won't sit around waiting for us to deal with this emergency before they give us a new one.
I guess I'd sentence those quarantine-defying students to three month farm labour. You insist on being outside? Get ploughing! But they'll need close supervision and constant instruction: they don't know how to do anything useful.
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Re: Mobile Home

Postby Faradave on April 2nd, 2020, 3:49 pm 

Serpent wrote: students … farm labour … they don't know how to do anything useful.

Duh, isn't there an app for that?

Serpent wrote:… unless this pandemic is the changer of how we conduct ourselves.

I'm hopeful. Handshaking was always kind of gross anyway. I don't think businesses can help but notice that some things are cheaper now that non-essential travel has been put under the glare of emergency. My grandson is "going to kindergarten" via Zoom; same with my wife's bible study group. Way better than Skype.

Also great for the environment but I feel bad for the hotel industry. Many could potentially convert to dormitory-style condos or assisted living facilities. A large franchise, like Marriott, Hilton, 4 Seasons could offer residents the option of rotating locations up to 3 times a year. Savor the world … gradually.
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Re: Year of the Rat fears over new Corona Virus

Postby Serpent on April 2nd, 2020, 4:08 pm 

I already volunteered all those excess passenger aircraft for housing the homeless, but I'm sure the designated tenants won't mind re-routing to a Holiday Inn. That way, the old folks can live in the airplanes and travel without having to pack and unpack every three months.
Now, about the idiotic luxury cruise ships...

With a little imagination and a lot of good will, we can re-purpose everything we won't need anymore.
Hey, it' just an economy! We can always make a new one.
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Re: Year of the Rat fears over new Corona Virus

Postby TheVat on April 4th, 2020, 10:17 am 

https://www.targetedonc.com/news/leronl ... oronavirus


CytoDyn, the developer of leronlimab, had filed an Investigational New Drug (IND) application and protocol with the FDA at the beginning of March for the initiation of the trial.2 Two weeks later, the FDA cleared an emergency IND to allow for the treatment of 2 patients with COVID-19 in New York with leronlimab therapy.3 Already a total of 10 severely ill patients have been treated with the CCR5 antagonist.

CytoDyn, developer of leronlimab announced in a press release that after 3 days of treatment with leronlimab, 8 patients with COVID-19 who are seriously ill have shown an improvement in several important immunologic biomarkers, including cytokines, interleukin (IL)-6, and a trend toward the normalization of the CD4/CD8 ratio.5

“We are very pleased with our most recent laboratory data for patients treated with leronlimab for COVID-19 infection. We continue to see increases in the profoundly decreased CD8 T-lymphocyte percentages by Day 3, normalization of CD4/CD8 ratios, and resolving cytokine production including reduced IL-6 correlating with patient improvement. The current data suggests a trend toward the restoration of immune function and mitigation of the cytokine storm. This is consistent with prior laboratory results in the first four patients treated for COVID-19 with leronlimab,” Bruce Patterson, MD, CEO and founder of IncellDx, a partner of CytoDyn’s, said in a statement.5

The randomized, double-blind, placebo-controlled phase II study of leronlimab as treatment of COVID-19 is expected to include 75 patients from up to 10 treatment centers in the United States. CytoDyn has also filed for the initiation of a phase II/III trial for the treatment of severely ill patients with COVID-19. This double-blind trial is expected to enroll 342 patients and randomize them in a 2:1 ratio. The primary end point of this trial is the mortality rate at 14 days.6
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Re: Year of the Rat fears over new Corona Virus

Postby toucana on April 8th, 2020, 2:24 pm 

According to a CNN report, US intelligence officials were warning as far back as late November that the novel coronavirus was spreading through China's Wuhan region and posing a threat to its people and daily life, according to ABC News.

https://edition.cnn.com/2020/04/08/politics/us-intelligence-report-china-coronavirus/index.html

The US military's National Center for Medical Intelligence (NCMI) compiled a November intelligence report in which "analysts concluded it could be a cataclysmic event," one of the sources of the NCMI's report told ABC News.

The source told ABC News that the intelligence report was then briefed "multiple times" to the Defense Intelligence Agency, the Pentagon's Joint Staff and the White House.

Repeated briefings were held through December across the US government, including the National Security Council, culminating in a detailed outline of the threat in the President's Daily Brief in early January, according to ABC News, whose report cited four sources briefed on the matter.

https://abcnews.go.com/Politics/intelligence-report-warned-coronavirus-crisis-early-november-sources/story?id=70031273

The report was the result of analysis of wire and computer intercepts, coupled with satellite images. It raised alarms because an out-of-control disease would pose a serious threat to U.S. forces in Asia.
"The timeline of the intel side of this may be further back than we’re discussing," the source said of preliminary reports from Wuhan. "But this was definitely being briefed beginning at the end of November as something the military needed to take a posture on."
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Re: Year of the Rat fears over new Corona Virus

Postby TheVat on April 11th, 2020, 10:20 am 

https://www.nationalgeographic.com/scie ... n-the-sky/

(if you get what looks like a paywall, it's not really one, just a request to enter an email address - you can make something up if you don't want ad emails in your box)

An interesting survey of some of the effects, and issues raised, of precipitous drops in urban traffic and smokestack output.
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Re: Year of the Rat fears over new Corona Virus

Postby Serpent on April 11th, 2020, 11:05 am 

Wow! That's a biggie. How easy will this be to bury, once The Holy Economy is Back on Track?
(As we speak, in the corner of my eye, a procession of cartoonish robber barons are tiptoeing away with great sacks of government cash.)
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Re: Year of the Rat fears over new Corona Virus

Postby TheVat on April 13th, 2020, 11:23 am 

Yes, we don't want people to start thinking clean air is normal, heheh.

Meanwhile, here is more of what Badger was talking about, as economic consequences land on those most vulnerable....


In the Persian Gulf, migrant workers face poverty and fear. - NY times, today

Millions of migrant workers in Persian Gulf countries have found themselves locked down, laid off and stranded, with no place to turn for help amid the coronavirus outbreak. Qatar alone has locked down tens of thousands of migrant workers in a crowded neighborhood, raising fears of a rampant spread of the virus there.

Companies in Saudi Arabia have told foreign laborers to stay home — then stopped paying them. In Kuwait, an actress said on television that migrants should be thrown out “into the desert.”

The oil-rich monarchies of the Persian Gulf have long relied on armies of low-paid migrant workers from Asia, Africa and elsewhere to do the heavy lifting in their economies, and have faced criticism from rights groups for treating those laborers poorly.

Now, the coronavirus has made matters worse, as migrants in Gulf States are locked down in cramped, unsanitary dorms, deprived of income and unable to return home because of travel restrictions.

Some are running out of food and money, and fear that they have no place to turn in societies that often treat them like an expendable underclass.

“Nobody called us,” said Mohamed al-Sayid, an Egyptian restaurant worker who lives with seven friends in a one-room apartment in Jeddah, Saudi Arabia — and all are now unemployed. “Nobody checked on us at all. I’m not afraid of corona. I’m afraid we’ll die from hunger.”
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Re: Year of the Rat fears over new Corona Virus

Postby Serpent on April 13th, 2020, 11:44 am 

This situation is shining a whole lot of unwelcome spotlights on the way we've been doing business.
Psst: Industrial, corporate capitalism may not be the very best economic system ever devised. Globalization may actually have some of the flaws its critics warned about early on.
The governments that are now faced with quandaries are also offered opportunities.
https://www.cbc.ca/news/canada/montreal/covid-19-quebec-economy-protectionism-1.5528781
The west is not going to rescue the east.
The west is going to scramble, for quite a long time, just to save itself.
The far east and middle east will have to figure out what works for them, nation by nation.
There will be a whole lot of casualties - as there always are, in global upheavals - but there may also be ---
just the tiniest glimmer, flickering and far off ---
hope.
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Re: Year of the Rat fears over new Corona Virus

Postby BadgerJelly on April 14th, 2020, 3:21 am 

Bit more of a focus from Bill Gates on how international unity is important and what needs to be done to help less developed countries:

https://m.youtube.com/watch?v=ie6lRKAdvuY
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Re: Year of the Rat fears over new Corona Virus

Postby Serpent on April 14th, 2020, 8:39 am 

I wish it were not always videos! I have limited bandwidth out in the boonies; I'm saving it for the one show on Prime to enjoy with my one beer, that I look forward to all day.
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Re: Year of the Rat fears over new Corona Virus

Postby TheVat on April 16th, 2020, 11:25 am 

https://www.npr.org/sections/coronavirus-live-updates/2020/04/16/835748673/in-vietnam-there-have-been-fewer-than-300-covid-19-cases-and-no-deaths-heres-why?utm_medium=RSS&utm_campaign=nprblogscoronavirusliveupdates

Prime Minister Nguyen Xuan Phuc recently characterized Vietnam's efforts as the "spring general offensive of 2020," a reference to the 1968 Tet Offensive that many claim helped turn the tide of the Vietnam War.

Tens of thousands have been put in quarantine camps. By the end of March, Vietnam had banned all international and domestic flights. The government locked down the country on April 1. State-run media say the current social distancing and stay-at-home orders are to be extended for at least another week.

Those who break the rules in this one-party Communist state are treated harshly. One man was jailed on a nine-month sentence for failing to wear a mask.
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Re: Year of the Rat fears over new Corona Virus

Postby toucana on April 19th, 2020, 8:43 am 

Japan’s emergency medical system has effectively collapsed according to observers.

https://www.independent.co.uk/news/world/asia/coronavirus-japan-death-toll-covid-19-cases-hospitals-ppe-latest-updates-a9472656.html

Hospitals in Japan are increasingly turning away sick people as the country struggles with surging coronavirus infections and its emergency medical system collapses.

In one recent case, an ambulance carrying a man with a fever and breathing difficulty was rejected by 80 hospitals and forced to search for hours for a hospital in downtown Tokyo that would treat him.

The Japanese Association for Acute Medicine and the Japanese Society for Emergency Medicine say many hospital emergency rooms are refusing to treat people including those suffering strokes, heart attacks and external injuries.

Japan initially appeared to have the outbreak of COVID-19 under control, in spite of its proximity to China; but a political reluctance to impose a full lock-down, and a native aversion to social distancing measures has now set the country on course for a catastrophe.

Japan lacks enough hospital beds, medical workers or equipment. Forcing anyone with the virus into hospital, even those with mild symptoms, has left hospitals overcrowded and understaffed, and has also overloaded the small number of acute care centres.

With some 10,000 cases and 170 deaths, Japan's situation is not as dire as many other countries, but there are fears its outbreak could become much worse.

A government virus task force has warned that, in a worst-case scenario where no preventive measures were taken, more than 400,000 could die due to shortages of ventilators and other intensive care equipment.

Shinzo Abe, the prime minister, has said the government has secured 15,000 ventilators and is getting support of Sony and Toyota Motor Corp. to produce more.

Japanese hospitals also lack ICUs, with only five per 100,000 people, compared to about 30 in Germany, 35 in the U.S. and 12 in Italy, said Osamu Nishida, head of the Japanese Society of Intensive Care Medicine.
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Re: Year of the Rat fears over new Corona Virus

Postby toucana on April 22nd, 2020, 4:28 am 

Coronavirus patients taking hydroxychloroquine were no less likely to need mechanical ventilation and had higher deaths rates compared to those who did not take the drug, according to a study of hundreds of patients at US Veterans Health Administration medical centers.

https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1

The study, which reviewed veterans' medical charts, was posted Tuesday on medrxiv.org, a pre-print server, meaning it was not peer reviewed or published in a medical journal. The research was funded by the National Institutes of Health and the University of Virginia.

In the study of 368 patients, 97 patients who took hydroxychloroquine had a 27.8% death rate. The 158 patients who did not take the drug had an 11.4% death rate.

Researchers also looked at whether taking hydroxychloroquine or a combination of hydroxychloroquine and the antibiotic azithromycin, had an effect on whether a patient needed to go on a ventilator.
CONCLUSIONS: In this study, we found no evidence that use of hydroxychloroquine, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with Covid-19. An association of increased overall mortality was identified in patients treated with hydroxychloroquine alone. These findings highlight the importance of awaiting the results of ongoing prospective, randomized, controlled studies before widespread adoption of these drugs.
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Re: Year of the Rat fears over new Corona Virus

Postby TheVat on April 22nd, 2020, 9:59 am 

https://www.rte.ie/news/2020/0418/11322 ... -covid-19/

There is currently no evidence to support the belief that people who have recovered from coronavirus then have immunity, the World Health Organization has said.

Senior WHO epidemiologists warned despite the hopes governments across the world have piled on antibody tests, there is no proof those who have been infected cannot be infected again.

Many tests being developed are pinprick blood tests similar to widely used instant HIV tests and measure for raised levels of the antibodies the body uses to fight the virus.

Speaking at a press conference in Geneva, Dr Maria van Kerkhove said: "There are a lot of countries that are suggesting using rapid diagnostic serological tests to be able to capture what they think will be a measure of immunity.

"Right now, we have no evidence that the use of a serological test can show that an individual has immunity or is protected from reinfection."

She added: "These antibody tests will be able to measure that level of seroprevalence - that level of antibodies but that does not mean that somebody with antibodies means that they are immune."


The WHO's top emergency expert Mike Ryan said that even if antibodies were effective there was little sign that large numbers of people had developed them and were beginning to offer so-called "herd immunity" to the broader population.

"A lot of preliminary information coming to us right now would suggest quite a low percentage of population have seroconverted (to produce antibodies)," Mr Ryan said.
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Re: Surviving the Data

Postby Faradave on April 22nd, 2020, 11:51 am 

If antibodies don't protect, then a vaccine won't work.

Then the only point of sheltering is to delay-spread demand for ventilators (which has largely been accomplished).

Without herd immunity, eventually everyone will have been exposed and only the strong will survive.

First credible but not conclusive data against hydroxychloroquine.
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Re: Year of the Rat fears over new Corona Virus

Postby TheVat on April 22nd, 2020, 12:58 pm 

Thanks, yes, I saw that study at medrxiv, to which toucan posted a link. I'd have preferred you post the link to other than Fox News, but it's no biggie. At least Fox noted that it's just a retrospective analysis of data, and didn't adjust for severity of cases, quality of care, etc. And they noted the need for results from double-blind trials and so on. For a Fox News story, it was remarkable. Maybe it helped them when Trump transferred his infatuation to the OANN network...


And yeah, that antibody story was a wee bit disturbing. Not too keen on the possibility of second and third waves coming in and knocking down those who had just enough strength to get through one bout of CV19. Hoping evidence for seroimmunity turns up.
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Re: Year of the Rat fears over new Corona Virus

Postby BadgerJelly on April 22nd, 2020, 1:29 pm 

There are no reported cases of anyone getting reinfected. I think it’d fairly safe to say people who’ve had won’t get hit again.

Note: There are cases of ‘relapse’ mistakenly reported as being ‘reinfected’.
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Re: Year of the Rat fears over new Corona Virus

Postby toucana on April 22nd, 2020, 7:54 pm 

Chinese researchers at Zhejiang University have discovered more than 30 mutations on the new coronavirus, which they say may partly explain why it has been more deadly in certain parts of the world.

https://news.sky.com/story/coronavirus-has-mutated-into-more-than-30-strains-say-scientists-in-china-11976380

Researchers from Zhejiang University said they have "direct evidence" that the virus "has acquired mutations capable of substantially changing its pathogenicity".

The study was written by a team including Professor Li Lanjuan, one of China's top scientists who was reportedly the first expert to propose a lockdown in Wuhan - where COVID-19 originated.
Samples were taken from 11 patients admitted to hospitals in Hangzhou, 470 miles east of Wuhan, between 22 January and 4 February during the early phase of the outbreak.

Using "ultra-deep sequencing", researchers identified 33 mutations of the coronavirus - known as SARS-CoV-2 - of which 19 were new

The deadliest mutations in the patients in the study had also been found in most patients across Europe, the South China Morning Post reported.

The researchers say vaccine developers need to consider the impact of these "accumulating mutations... to avoid potential pitfalls".

The same would presumably apply to antibody testing as well.
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Re: Year of the Rat fears over new Corona Virus

Postby toucana on April 23rd, 2020, 9:26 am 

Nicotine patches are to be tested on coronavirus patients and healthcare workers treating infected people after initial studies suggested smokers were less likely to catch the disease.

https://news.sky.com/story/coronavirus-nicotine-patches-to-be-tested-on-patients-after-study-suggests-smokers-less-likely-to-catch-covid-19-11977460

Researchers in France say early data indicates those who smoke make up a disproportionately small number of people in hospital with COVID-19.

A study at Paris's Pitie-Salpetriere hospital suggests a substance in tobacco, thought to be nicotine, was preventing smokers contracting coronavirus.
.. after questioning 480 patients who tested positive for the virus. A total of 350 had to be treated in hospital while the rest with less serious symptoms were sent home.


Of those needing hospital treatment, whose median age was 65, just 4.4% were regular smokers. Only 5.3% of those allowed home - who had a median age of 44 - 5.3% reported they smoked.

The researchers said that according to the latest official statistics in France, smokers make up 30% of those aged 45-54, and 8.8% of women and 11.3% of men aged 65-75.

The authors write: "Our cross-sectional study strongly suggests that daily smokers have a much lower probability of developing symptomatic or severe SARS-CoV-2 infection compared to the general population.

"The effect is significant, it divides the risk by five for ambulatory patients and by four for hospitalised patients. You rarely see that in medicine."

Eminent neurobiologist Jean-Pierre Changeux, who has reviewed the work, speculated that nicotine could protect against the virus by preventing it reaching the body's cells.

It is also thought that nicotine could prevent the immune system going into overdrive due to the infection, as has been seen among some of the worst-affected cases.


Footnote:
Shades of 1665 ! — c.f. my recent post in ‘Books, Media & Internet Resources’

http://www.sciencechatforum.com/viewtopic.php?f=79&p=350347#p350347

[“Calculus And Tobacco - Journal Of The Plague Year”]
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Re: Year of the Rat fears over new Corona Virus

Postby TheVat on April 23rd, 2020, 9:54 am 

Another day, another weird French study.

Researchers in France say early data indicates those who smoke make up a disproportionately small number of people in hospital with COVID-19.


I have to wonder if this is a misleading correlation, which appears because people who would be more vulnerable to severe CV have already, due to prior medical conditions, given up smoking.
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Re: Year of the Rat fears over new Corona Virus

Postby Forest_Dump on April 23rd, 2020, 9:58 am 

Finally a possible upside to being a smoker. Choke on that you pink lungers!
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Re: Year of the Rat fears over new Corona Virus

Postby Serpent on April 23rd, 2020, 10:15 am 

TheVat » April 23rd, 2020, 8:54 am wrote:Another day, another weird French study.

I have to wonder if this is a misleading correlation, which appears because people who would be more vulnerable to severe CV have already, due to prior medical conditions, given up smoking.

Or else the fragile smokers have died of heart disease or lung cancer.
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Re: Year of the Rat fears over new Corona Virus

Postby toucana on April 24th, 2020, 2:57 am 

Alternatively, if tobacco consumption with a view to using nicotine to mitigate cytokine storm effects is considered to be too risky and uncertain, then doctors could try President Trump's latest suggestion of injecting sunshine and disinfectant into patients as a way of treating COVID-19 ?

https://www.bbc.co.uk/news/world-us-canada-52407177
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Re: Year of the Rat fears over new Corona Virus

Postby bangstrom on April 24th, 2020, 5:43 am 

I suggest in Trump's case that the internal UV light not be inserted orally.
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Re: Year of the Rat fears over new Corona Virus

Postby TheVat on April 24th, 2020, 9:31 am 

But then the light would have to somehow get around his head, which currently blocks that passage.

I really hope that some Red Hat fool doesn't get killed by trying to inject or imbibe disinfectant solution.
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Re: Year of the Rat fears over new Corona Virus

Postby Forest_Dump on April 24th, 2020, 9:40 am 

I didn't quite believe this one at first but then heard so much more and was gob smacked. But I would take a bit of a different tack. Maybe some Trump supporters should be encouraged to drink or inject large quantities of bleach, etc., if they are so inclined. Maybe it really is time for a bit more natural selection.
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Re: Year of the Rat fears over new Corona Virus

Postby Serpent on April 24th, 2020, 1:04 pm 

bangstrom » April 24th, 2020, 4:43 am wrote:I suggest in Trump's case that the internal UV light not be inserted orally.

You are far too kind and clean-minded. I have another idea.

There is a rumour that several White House officials have been sacked because they were heard muttering "fuggin moran, fuggin moran" .
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Re: Year of the Rat fears over new Corona Virus

Postby toucana on April 24th, 2020, 6:13 pm 

The mystery of Trump’s remarks about injecting sunshine and disinfectant to combat COVID-19 has been resolved, to some extent, by his subsequent elucidation that he was “Only being sarcastic” when he uttered them.

https://news.sky.com/story/donald-trump-i-was-being-sarcastic-about-using-disinfectant-as-a-covid-19-cure-11978400

Sarcasm is of course a tool that statesmen frequently make use of when addressing their nation at a time of deep national crisis.

I am told that British prime minister Winston Churchill when rehearsing his famous speech in June 1940, as Britain faced an imminent invasion by Hitler’s armies, originally offered these immortal words
We shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the fields and in the streets, we shall fight in the hills; we shall never surrender, and if all else fails… we shall beat them over the head with bottles, because that’s about all we’ve bloody well got.”
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Re: Year of the Rat fears over new Corona Virus

Postby toucana on April 24th, 2020, 6:37 pm 

The really frightening thing is that there are apparently commercial fraudsters trying to promote bleach consumption as a panacea for killing all known germs including COVID-19.

https://www.theguardian.com/world/2020/apr/24/revealed-leader-group-peddling-bleach-cure-lobbied-trump-coronavirus

The leader of one such American industrial consortium is a man called Mark Grenon who according to this report in the Guardian newspaper wrote to President Donald Trump several days ago hyping the merits of chlorine dioxide bleach.

This may well have been the original source of Trump's lunatic suggestion.
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